Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients.


Autoria(s): Roca-Rodríguez, M M; García-Almeida, J M; Lupiáñez-Pérez, Y; Rico, J M; Toledo, M; Alcaide-Torres, J; Cardona, F; Medina, J A; Tinahones, F J
Data(s)

23/03/2015

23/03/2015

01/01/2014

Resumo

Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplement, on markers of inflammation, oxidative stress and metabolic status of ENT cancer patients undergoing radiotherapy (RT). Fourteen days after starting RT, 26 patients were randomly allocated to one of two groups, 13 supplemented with Prosure, an oncologic formula enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes (specific supplement), and 13 supplemented with Standard-Isosource (standard supplement). Patients were evaluated before RT, and 14, 28 and 90 days after starting RT. The results showed that there were no significant differences between the groups, but greater changes were observed in the standard supplement group, such as a decline in body mass index (BMI), reductions in hematocrit, erythrocyte, eosinophil and albumin levels, and a rise in creatinine and urea levels. We concluded that metabolic, inflammatory and oxidative stress parameters were altered during RT, and began to normalize at the end of the study. Patients supplemented with Prosure showed an earlier normalization of these parameters, with more favorable changes in oxidative stress markers and a more balanced evolution, although the difference was not significant.

Journal Article; Research Support, Non-U.S. Gov't;

This study was supported in part by grants from the Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación, EC07/90285). F. Cardona is a recipient of CP07/0095 grant. M.M. Roca-Rodríguez is supported by fellowship Rio Hortega CM11/00030 Program from the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness. Trial registration, EudraCT Number 2008-000330-50.

Identificador

Roca-Rodríguez MM, García-Almeida JM, Lupiáñez-Pérez Y, Rico JM, Toledo M, Alcaide-Torres J, et al. Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients. Oncol. Rep.. 2014; 31(1):405-14

1791-2431 (Online)

1021-335X (Print)

http://hdl.handle.net/10668/1853

24154820

10.3892/or.2013.2806

Idioma(s)

en

Publicador

Spandidos Publications

Relação

Oncology reports

http://www.spandidos-publications.com/or/31/1/405

Direitos

Acceso abierto

Palavras-Chave #Metabolic status #Radiotherapy #IL6 protein, human #Interleukin-6 #Hydrogen Peroxide #n-3 polyunsaturated fatty acids #Oxidative stress #Inflammaation #Metabolic status #Suplementos dietéticos #Neoplasias del oído #Electrólitos #Ácidos grasos insaturados #Glutatión peroxidasa #Peróxido de hidrógeno #Inflamación #Interleucina-6 #Desnutrición #Neoplasias nasale #Estrés oxidativo #Neoplasias Faríngeas #Antioxidantes #Índice de masa corporal #Proteína C-reactiva #Fibras en la dieta #Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Protein #Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Fiber #Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Supplements #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Ear Neoplasms #Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Electrolytes #Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated #Medical Subject Headings::Check Tags::Female #Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidase #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Electrolytes::Ions::Anions::Oxides::Peroxides::Hydrogen Peroxide #Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6 #Medical Subject Headings::Check Tags::Male #Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Nose Neoplasms #Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Pharyngeal Neoplasms #Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo