In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
| Data(s) |
01/06/2015
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|---|---|
| Resumo |
We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity. |
| Formato |
text/html |
| Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566 |
| Idioma(s) |
en |
| Publicador |
Instituto Oswaldo Cruz, Ministério da Saúde |
| Fonte |
Memórias do Instituto Oswaldo Cruz v.110 n.4 2015 |
| Palavras-Chave | #Trypanosoma cruzi #antitrypanosomal agents #Chagas disease #1,3-bisaryloxypropanamines |
| Tipo |
journal article |
