Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?
Data(s) |
11/09/2015
11/09/2015
01/07/2013
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Resumo |
One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy. Journal Article; Research Support, Non-U.S. Gov't; Review; This study was supported by the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (PI08/0728, Fondos FEDER) to M.I. Núñez. F. Artacho-Cordón is supported by the Spanish Ministry of Science and Education ( AP2012-2524). |
Identificador |
Artacho-Cordón F, Salinas-Asensio Mdel M, Calvente I, Ríos-Arrabal S, León J, Román-Marinetto E, et al. Could radiotherapy effectiveness be enhanced by electromagnetic field treatment? Int J Mol Sci. 2013; 14(7):14974-95 1422-0067 (Online) PMC3742283 http://hdl.handle.net/10668/1992 23867611 10.3390/ijms140714974 |
Idioma(s) |
en |
Publicador |
MPID |
Relação |
International Journal of Molecular Sciences http://www.mdpi.com/1422-0067/14/7/14974 |
Direitos |
Acceso abierto |
Palavras-Chave | #ELF Magnetic Exposure #Electromagnetic Fields #Cancer #Radiotherapy #Genotocity #Campos electromagnéticos #Neoplasias #Radiación ionizante #Sistema de señalización de quinasas PAM #Medical Subject Headings::Anatomy::Cells::Cellular Structures::Cell Membrane #Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus #Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Magnetic Phenomena::Electromagnetic Phenomena::Electromagnetic Fields #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction::MAP Kinase Signaling System #Medical Subject Headings::Diseases::Neoplasms #Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Radiation::Radiation, Ionizing #Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Radiation-Sensitizing Agents #Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/published Revisión |