Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.


Autoria(s): Bai P.; Nagy L.; Fodor T.; Liaudet L.; Pacher P.
Data(s)

2015

Resumo

Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.

Identificador

http://serval.unil.ch/?id=serval:BIB_47586F9211AB

isbn:1879-3061 (Electronic)

pmid:25497347

doi:10.1016/j.tem.2014.11.003

isiid:000349729400003

Idioma(s)

en

Fonte

Trends In Endocrinology and Metabolism, vol. 26, no. 2, pp. 75-83

Tipo

info:eu-repo/semantics/review

article