Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.
Data(s) |
2015
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Resumo |
Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondrial damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues. |
Identificador |
http://serval.unil.ch/?id=serval:BIB_47586F9211AB isbn:1879-3061 (Electronic) pmid:25497347 doi:10.1016/j.tem.2014.11.003 isiid:000349729400003 |
Idioma(s) |
en |
Fonte |
Trends In Endocrinology and Metabolism, vol. 26, no. 2, pp. 75-83 |
Tipo |
info:eu-repo/semantics/review article |