Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].


Autoria(s): Bochud Murielle; Vollenweider Peter; Waeber Gérard
Data(s)

2011

Resumo

Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.

Identificador

http://serval.unil.ch/?id=serval:BIB_474E8F7C5646

isbn:1660-9379 (Print)

pmid:22187784

http://rms.medhyg.ch/numero-315-page-2142.htm

Idioma(s)

fr

Direitos

info:eu-repo/semantics/openAccess

Fonte

Revue Médicale Suisse, vol. 7, no. 315, pp. 2142, 2144-2142, 2145

Palavras-Chave #Biological Markers/blood; Cardiovascular Diseases/blood; Cardiovascular Diseases/mortality; Cohort Studies; Glucose Transport Proteins, Facilitative/blood; Gout/blood; Gout/epidemiology; Humans; Hyperuricemia/blood; Hyperuricemia/epidemiology; Risk Factors; Switzerland/epidemiology; Uric Acid/blood
Tipo

info:eu-repo/semantics/article

article