Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Data(s) |
2011
|
---|---|
Resumo |
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far. |
Identificador |
http://serval.unil.ch/?id=serval:BIB_474E8F7C5646 isbn:1660-9379 (Print) pmid:22187784 |
Idioma(s) |
fr |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Revue Médicale Suisse, vol. 7, no. 315, pp. 2142, 2144-2142, 2145 |
Palavras-Chave | #Biological Markers/blood; Cardiovascular Diseases/blood; Cardiovascular Diseases/mortality; Cohort Studies; Glucose Transport Proteins, Facilitative/blood; Gout/blood; Gout/epidemiology; Humans; Hyperuricemia/blood; Hyperuricemia/epidemiology; Risk Factors; Switzerland/epidemiology; Uric Acid/blood |
Tipo |
info:eu-repo/semantics/article article |