Effect of expiratory positive airway pressure on sleep disordered breathing.


Autoria(s): Heinzer R.; White D.P.; Malhotra A.; Lo Y.L.; Dover L.; Stevenson K.E.; Jordan A.S.
Data(s)

2008

Resumo

STUDY OBJECTIVES: We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients. DESIGN: Observational physiology study PARTICIPANTS: We studied 10 OSA patients during sleep wearing a facial mask. We recorded 1 hour of NREM sleep without treatment (baseline) and 1 hour with 10 cm H2O EPAP in random order, while measuring EELV and breathing pattern. RESULTS: The mean EELV change between baseline and EPAP was only 13.3 mL (range 2-25 mL). Expiratory time was significantly increased with EPAP compared to baseline 2.64 +/- 0.54 vs 2.16 +/- 0.64 sec (P = 0.002). Total respiratory time was longer with EPAP than at baseline 4.44 +/- 1.47 sec vs 3.73 +/- 0.88 sec (P = 0.3), and minute ventilation was lower with EPAP vs baseline 7.9 +/- 4.17 L/min vs 9.05 +/- 2.85 L/min (P = 0.3). For baseline (no treatment) and EPAP respectively, the mean apnea+hypopnea index (AHI) was 62.6 +/- 28.7 and 56.8 +/- 30.3 events per hour (P = 0.4). CONCLUSION: In OSA patients during sleep, the application of 10 cm H2O EPAP led to prolongation of expiratory time with only marginal increases in FRC. These findings suggest important mechanisms exist to avoid hyperinflation during sleep.

Identificador

http://serval.unil.ch/?id=serval:BIB_45F2449D9E24

isbn:0161-8105

pmid:18363320

isiid:000253577900017

Idioma(s)

en

Fonte

Sleep, vol. 31, no. 3, pp. 429-432

Palavras-Chave #Adult; Airway Resistance/physiology; Body Mass Index; Expiratory Reserve Volume/physiology; Female; Functional Residual Capacity/physiology; Humans; Male; Middle Aged; Oxygen/blood; Polysomnography; Positive-Pressure Respiration; Sleep Apnea, Obstructive/diagnosis; Sleep Apnea, Obstructive/physiopathology; Tidal Volume/physiology
Tipo

info:eu-repo/semantics/article

article