Influence of sodium intake on circulating levels of neuropeptide Y.


Autoria(s): Waeber B.; Corder R.; Aubert J.F.; Nussberger J.; Gaillard R.; Brunner H.R.
Data(s)

1987

Resumo

Neuropeptide Y (NPY) is present in the adrenal medulla, in sympathetic neurons as well as in the circulation. This peptide not only exerts a direct vasoconstrictor effect, but also potentiates the vasoconstriction evoked by norepinephrine and sympathetic nerve stimulation. The vasoconstrictor effect of norepinephrine is also enhanced by salt loading and reduced by salt depletion. The purpose of this study was therefore to assess whether there exists a relationship between dietary sodium intake and the levels of circulating NPY. Uninephrectomized normotensive rats were maintained for 3 weeks either on a low, a regular or a high sodium intake. On the day of the experiment, plasma levels of NPY and catecholamines were measured in the unanesthetized animals. There was no significant difference in plasma norepinephrine and epinephrine levels between the 3 groups of rats. Plasma NPY levels were the lowest (65.4 +/- 8.8 fmol/ml, n-10, Mean +/- SEM) in salt-restricted and the highest (151.2 +/- 25 fmol/ml, n-14, p less than 0.02) in salt-loaded animals. Intermediate values were obtained in rats kept on a regular sodium intake (117.6 +/- 20.1 fmol/ml). These findings are therefore compatible with the hypothesis that sodium balance might to some extent influence blood pressure regulation via changes in circulating NPY levels which in turn modify blood pressure responsiveness.

Identificador

http://serval.unil.ch/?id=serval:BIB_458B59B35016

isbn:0024-3205

pmid:3626763

isiid:A1987J653700009

Idioma(s)

en

Fonte

Life sciences, vol. 41, no. 11, pp. 1391-6

Palavras-Chave #Animals; Blood Pressure; Body Weight; Catecholamines; Diet; Heart Rate; Neuropeptide Y; Rats; Sodium
Tipo

info:eu-repo/semantics/article

article