Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil


Autoria(s): Marx,Camila; Gregianini,Tatiana Schaffer; Lehmann,Fernanda Kieling Moreira; Lunge,Vagner Ricardo; Carli,Silvia de; Dambros,Bibiana Paula; Tumioto,Gabriela Luchiari; Seadi,Claudete; Fonseca,Andre Salvador Kazantzi; Ikuta,Nilo
Data(s)

01/05/2013

Resumo

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

Formato

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Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000300392

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.108 n.3 2013

Palavras-Chave #influenza A(H1N1)pmd09 #resistance #oseltamivir
Tipo

journal article