Occult hepatitis B virus infection among injecting drug users in the Central-West Region of Brazil


Autoria(s): Matos,Marcia Alves Dias de; Ferreira,Renata Carneiro; Rodrigues,Fabiana Perez; Marinho,Tamiris Augusto; Lopes,Carmen Luci Rodrigues; Novais,Antonia Carlos Magalhaes; Motta-Castro,Ana Rita Coimbra; Teles,Sheila Araujo; Souto,Francisco Jose Dutra; Martins,Regina Maria Bringel
Data(s)

01/05/2013

Resumo

The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HBsAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil's Central-West Region.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000300386

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.108 n.3 2013

Palavras-Chave #hepatitis B virus #occult infection #genotypes
Tipo

journal article