Hepatitis C virus quantification in serum and saliva of HCV-infected patients


Autoria(s): Menezes,Gisele Barreto Lopes; Pereira,Fernanda Albuquerque; Duarte,César Augusto Barros; Carmo,Theomira Mauadie Azevedo; Silva Filho,Hermes Pedreira da; Zarife,Maria Alice; Krieger,Marco Aurélio; Reis,Eliana Almeida Gomes; Reis,Mitermayer G
Data(s)

01/08/2012

Resumo

The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500016

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.107 n.5 2012

Palavras-Chave #HCV #HCV transmission #serum HCV load #salivary HCV load
Tipo

journal article