Sphenoid sinus metastasis as the presenting manifestation of a prostatic adenocarcinoma: case report and overview of the literature.


Autoria(s): Puche-Sanz, I; Vázquez-Alonso, F; Flores-Martín, J F; Almonte-Fernández, H; Cózar-Olmo, J M
Data(s)

15/03/2013

15/03/2013

10/10/2012

Resumo

Although a metastatic presentation of an occult prostatic adenocarcinoma is not uncommon, the majority of these patients present with bone metastasis affecting the axial skeleton. Cranial metastases to the paranasal sinuses are extremely rare. A 56-year-old man presented with loss of vision and numbness of the right side of the face. Computed tomography (CT) scan and cranial magnetic resonance imaging (MRI) revealed a mass invading the sphenoid sinus. The patient underwent surgery to remove the lesion, and the histopathological examination suggested metastasis of an adenocarcinoma, with positive staining to prostatic specific antigen (PSA). However, serum PSA was 4 ng/mL, and the patient did not report any lower urinary tract symptoms or bone pain. Transrectal ultrasound-guided biopsy revealed prostatic adenocarcinomas with a Gleason score of 8 [4 + 4]. The subsequent treatment consisted of radiotherapy and androgen deprivation, followed by first- and second-line chemotherapy (docetaxel and cabazitaxel) when the disease progressed. The patient achieved a good response with the last cycle of cabazitaxel and after a 5-year followup is currently alive. Cranial metastases of prostate adenocarcinoma are rare, and there is currently no standard treatment for these patients. Whenever possible, surgery combined with radiotherapy and hormonotherapy is the recommended option.

Journal Article;

Identificador

Puche-Sanz I, Vázquez-Alonso F, Flores-Martín JF, Almonte-Fernández H, Cózar-Olmo JM. Sphenoid sinus metastasis as the presenting manifestation of a prostatic adenocarcinoma: case report and overview of the literature. Case Rep Oncol Med; 2012:819809

2090-6714 (Online)

2090-6706 (Print)

PMC3502819

http://hdl.handle.net/10668/840

23198202

10.1155/2012/819809

Idioma(s)

en

Publicador

Hindawi Publishing Corporation

Relação

Case Reports in Oncological Medicine

http://www.hindawi.com/crim/oncmed/2012/819809/abs/

Direitos

Acceso abierto

Palavras-Chave #Adenocarcinoma #Masculino #Neoplasias de la Próstata #Neoplasias de los Senos Paranasales #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Check Tags::Male #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms #Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Nose Neoplasms::Paranasal Sinus Neoplasms
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo