Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?


Autoria(s): Verge González, Carmen; Lucena González, María Isabel; López-Torres, Enrique; Puche-García, María José; Fraga, Enrique; Romero-Gómez, Manuel; Andrade Bellido, Raúl Jesús
Data(s)

11/03/2013

11/03/2013

21/08/2006

Resumo

Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.

Case Reports; Journal Article; Research Support, Non-U.S. Gov't;

Identificador

Verge González C, Lucena González MI, López-Torres E, Puche-García MJ, Fraga E, Romero-Gómez M, et al. Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs? World J. Gastroenterol.. 2006;12(31):5078-80

2219-2840 (Online)

1007-9327 (Print)

http://hdl.handle.net/10668/815

16937512

Idioma(s)

en

Publicador

Baishideng Publishing Group Co. Limited

Relação

World Journal of Gastroenterology : WJG

http://www.wjgnet.com/1007-9327/full/v12/i31/5078.htm

Direitos

Acceso abierto

Palavras-Chave #Calcium carbimide #Hepatotoxicity #Disuasivos de Alcohol #Cianamida #Disulfiram #Interacciones de Drogas #Hígado #Enfermedad Hepática Inducida por Drogas #Femenino #Humanos #Masculino #Mediana Edad #Adulto #Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Alcohol Deterrents #Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Hydrogen Cyanide::Cyanides::Cyanamide #Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates::Thiocarbamates::Ditiocarb::Disulfiram #Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions #Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver Injury #Medical Subject Headings::Check Tags::Female #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Anatomy::Digestive System::Liver #Medical Subject Headings::Check Tags::Male #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo