Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far.
Data(s) |
10/12/2012
10/12/2012
16/09/2011
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Resumo |
Pulmonary arterial hypertension is an infrequent but nevertheless serious life-threatening severe complication of HIV infection. It can be treated with bosentan and oral anticoagulants. Bosentan could induce the acenocoumarol metabolism and it increases the INR values. Until now, no study of interaction between bosentan and oral anticoagulants in HIV patients has reported. So we present a case of this interaction between these drugs and we reviewed MEDLINE to identify all the papers published so far. In our case, several weeks after increasing dose of bosentan acenocoumarol dose had to be progressively increased to 70 mg/week (+33%) without obtaining an adequate INR level (2.0-3.0). Forty-nine days later, we achieved a therapeutic INR with 90 mg/week of warfarin. The use of bosentan and oral anticoagulants together in these patients require a closer monitoring during first weeks of treatment, after increasing the bosentan dose and even during longer periods of time. Journal Article; |
Identificador |
Morales-Molina JA, Martínez-de la Plata JE, Urquízar-Rodríguez O, Molina-Arrebola MA. Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far. Hematol Rep. 2011 Aug; 3(2):e16 2038-8330 (Online) 2038-8322 (Print) http://hdl.handle.net/10668/699 22184537 10.4081/hr.2011.e16 |
Idioma(s) |
en |
Publicador |
PAGEPress Publications |
Relação |
Hematology reports http://www.pagepress.org/journals/index.php/hr/article/view/2946 |
Direitos |
Acceso abierto |
Palavras-Chave | #Drug Interactions #Interacciones de Drogas #HIV Patients #VIH #Acenocoumarol #Acenocumarol #Bosentan #Warfarin #Warfarina #Hipertensión Pulmonar #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Coumarins::4-Hydroxycoumarins::Acenocoumarol #Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Coumarins::4-Hydroxycoumarins::Warfarin #Medical Subject Headings::Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections #Medical Subject Headings::Named Groups::Persons::Patients |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/published Artículo |