Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance


Autoria(s): Tinahones Madueño, Francisco José; Cardona Díaz, Fernando; Rojo-Martínez, Gemma; Almaraz, María de la Cruz; Cardona, Isabel; Vázquez-Mellado, J; Garrido-Sánchez, Lourdes; Collantes, E; Soriguer Escofet, Federico
Data(s)

21/11/2012

21/11/2012

01/01/2008

Resumo

Hyperuricaemia is one of the components of metabolic syndrome. Both oxidative stress and hyperinsulinism are important variables in the genesis of this syndrome and have a close association with uric acid (UA). We evaluated the effect of an oral glucose challenge on UA concentrations. The study included 656 persons aged 18 to 65 years. Glycaemia, insulin, UA and plasma proteins were measured at baseline and 120 min after an oral glucose tolerance test (OGTT). The baseline sample also included measurements of total cholesterol, triacylglycerol (TAG) and HDL-cholesterol. Insulin resistance was calculated with the homeostasis model assessment. UA levels were significantly lower after the OGTT (281.93 (sd 92.19) v. 267.48 (sd 90.40) micromol/l; P < 0.0001). Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Multiple regression analysis showed that the basal TAG levels, insulin at 120 min, glycaemia at 120 min and waist:hip ratio significantly predicted the variance in the UA difference (r2 0.077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels.

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;

This study was undertaken with finance from the Fondo de Investigación Sanitaria ‘Centros de Investigación En Red’(CIBER, CB06/03/0018) of the ‘Instituto de Salud Carlos III’, SAF 2006/12 894 of the MCYT and FIS 05/1307 of the ‘Instituto de Salud Carlos III’, Madrid, Spain.

Identificador

Tinahones Madueño FJ, Cardona Díaz F, Rojo-Martínez G, Almaraz MC, Cardona I, Vázquez-Mellado J, et al. Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. Br. J. Nutr.. 2008; 99(1):44-8

1475-2662 (Online)

0007-1145 (Print)

http://hdl.handle.net/10668/629

17761018

10.1017/S0007114507787470

Idioma(s)

en

Publicador

Cambridge University Press

Relação

The British Journal of Nutrition

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1590632

Direitos

Acceso abierto

Palavras-Chave #OGTT #Glucemia #Colesterol #HDL-Colesterol #Prueba de Tolerancia a la Glucosa #Insulina #Resistencia a la Insulina #Estrés Oxidativo #Análisis de Regresión #Triglicéridos #Ácido úrico #Uric acid #Insulin resistance #OGTT #Triacylglycerol #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged #Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose #Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol #Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL #Medical Subject Headings::Check Tags::Female #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis::Glucose Tolerance Test #Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins #Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance #Medical Subject Headings::Check Tags::Male #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged #Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis #Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerides #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Xanthines::Uric Acid #Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo