Notch tumor suppressor function
Data(s) |
2008
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Resumo |
Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway is critically context dependent. Here we review the pro-differentiation role and tumor suppressing function of this pathway, as revealed by loss-of-function in keratinocytes and skin, downstream of p53 and in cross-connection with other determinants of stem cell potential and/or tumor formation, such as p63 and Rho/CDC42 effectors. The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy |
Identificador |
https://serval.unil.ch/notice/serval:BIB_3DB0E583975D info:pmid:18758480 https://serval.unil.ch/resource/serval:BIB_3DB0E583975D.P001/REF http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3DB0E583975D0 urn:nbn:ch:serval-BIB_3DB0E583975D0 |
Idioma(s) |
eng |
Fonte |
Oncogene27385115-5123 |
Palavras-Chave | #adverse effects; Animals; Apoptosis; Cell Differentiation; Cell Transformation,Neoplastic; DNA Damage; Female; Genes,Tumor Suppressor; genetics; Humans; Keratinocytes; Mice; Neoplasms; Oncogene Proteins,Viral; pathology; physiology; physiopathology; radiation effects; Receptor,Notch1; Receptors,Notch; Signal Transduction; Species Specificity; Switzerland; therapy; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Tumor Virus Infections; Ultraviolet Rays; Uterine Cervical Neoplasms; virology |
Tipo |
info:eu-repo/semantics/review article |
Formato |
application/pdf |
Direitos |
info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer |