Notch tumor suppressor function


Autoria(s): Dotto, G. P.
Data(s)

2008

Resumo

Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway is critically context dependent. Here we review the pro-differentiation role and tumor suppressing function of this pathway, as revealed by loss-of-function in keratinocytes and skin, downstream of p53 and in cross-connection with other determinants of stem cell potential and/or tumor formation, such as p63 and Rho/CDC42 effectors. The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy

Identificador

https://serval.unil.ch/notice/serval:BIB_3DB0E583975D

info:pmid:18758480

https://serval.unil.ch/resource/serval:BIB_3DB0E583975D.P001/REF

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3DB0E583975D0

urn:nbn:ch:serval-BIB_3DB0E583975D0

Idioma(s)

eng

Fonte

Oncogene27385115-5123

Palavras-Chave #adverse effects; Animals; Apoptosis; Cell Differentiation; Cell Transformation,Neoplastic; DNA Damage; Female; Genes,Tumor Suppressor; genetics; Humans; Keratinocytes; Mice; Neoplasms; Oncogene Proteins,Viral; pathology; physiology; physiopathology; radiation effects; Receptor,Notch1; Receptors,Notch; Signal Transduction; Species Specificity; Switzerland; therapy; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Tumor Virus Infections; Ultraviolet Rays; Uterine Cervical Neoplasms; virology
Tipo

info:eu-repo/semantics/review

article

Formato

application/pdf

Direitos

info:eu-repo/semantics/openAccess

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