Steroid hormone pulsing drives cyclic gene expression.
| Data(s) |
2009
|
|---|---|
| Resumo |
Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_3B2B3C0EA410 isbn:1476-4679[electronic] pmid:19724259 doi:10.1038/ncb0909-1051 isiid:000269482500005 |
| Idioma(s) |
en |
| Fonte |
Nature Cell Biology, vol. 11, no. 9, pp. 1051-1053 |
| Palavras-Chave | #Adrenal Cortex Hormones/blood; Adrenal Cortex Hormones/pharmacology; Animals; Gene Expression Regulation/drug effects; Humans; Mice; Models, Biological; Rats; Receptors, Glucocorticoid/metabolism; Response Elements/genetics; Transcription, Genetic/drug effects |
| Tipo |
info:eu-repo/semantics/article article |
