PACHYCHOROID: an inherited condition?


Autoria(s): Lehmann M.; Bousquet E.; Beydoun T.; Behar-Cohen F.
Data(s)

2015

Resumo

PURPOSE: Thick choroid (pachychoroid) is associated with central serous chorioretinopathy (CSC), but whether pachychoroid is inherited is unknown. METHODS: In a prospective observational study, first- or second-degree relatives (16 individuals) of 5 patients with CSC had refraction and visual acuity measurement, fundus examination, nonmydriatic photography, and autofluorescence photography. Eyes were graded using the following criteria: 0: normal fundus and autofluorescence photography, 1: focal retinal pigment epithelium hyperfluorescence and/or hypofluorescence and/or retinal pigment epithelial detachment, 2: CSC or diffuse retinal epitheliopathy. Choroid thickness was measured by enhanced depth imaging mode on optical coherence tomography. RESULTS: Considering 395 μm as the threshold limit for normal subfoveal choroidal thickness, 50% of the eyes from relatives had a thick choroid. Nine eyes of Grade 0 (28%) with an isolated pachychoroid would thus have been considered normal, if choroidal thickness was not included as a screening sign predisposing for CSC. CONCLUSION: Our observation suggests that pachychoroid could be an inherited condition with potentially a dominant transmission mode. Its inclusion in the phenotype of CSC for genetic studies should be considered.

Identificador

http://serval.unil.ch/?id=serval:BIB_3A67608725DA

isbn:1539-2864 (Electronic)

pmid:25046398

doi:10.1097/IAE.0000000000000287

isiid:000347060000012

http://my.unil.ch/serval/document/BIB_3A67608725DA.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3A67608725DA6

Idioma(s)

en

Direitos

info:eu-repo/semantics/openAccess

Fonte

Retina, vol. 35, no. 1, pp. 10-16

Tipo

info:eu-repo/semantics/article

article