Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor.


Autoria(s): Balsa, Alejandro; Cabezón, Arancha; Orozco, Gisela; Cobo, Tatiana; Miranda-Carus, Eugenia; López-Nevot, Miguel Angel; Vicario, José Luis; Martín-Mola, Emilio; Martín, Javier; Pascual-Salcedo, Dora
Data(s)

21/11/2012

21/11/2012

06/04/2010

Resumo

INTRODUCTION The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF). METHODS We studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined. RESULTS We found an increased frequency of HLA DRB1 alleles with the shared epitope (SE) in ACPA-positive RA. Inversely, HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA, and a similar trend was found for HLA DR3. However, these results could not be confirmed after stratification for the presence of the SE, probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found. CONCLUSIONS HLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA.

Journal Article; Research Support, Non-U.S. Gov't;

This work was supported by Fundacion Mutua Madrileña PI-668 and Beca FER-Abbott 2004

Identificador

Balsa A, Cabezón A, Orozco G, Cobo T, Miranda-Carus E, López-Nevot MA, et al. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res. Ther.; 12(2):R62

1478-6362 (Online)

1478-6354 (Print)

http://hdl.handle.net/10668/634

20370905

10.1186/ar2975

Idioma(s)

en

Publicador

BioMed Central

Relação

Arthritis research & therapy

http://arthritis-research.com/content/12/2/R62

Direitos

Acceso abierto

Palavras-Chave #Secuencias de Aminoácidos #Artritis Reumatoide #Autoanticuerpos #Epítopos #Femenino #Marcadores Genéticos #Predisposición Genética a la Enfermedad #Antígenos HLA-DR #Cadenas HLA-DRB1 #Humanos #Masculino #Mediana Edad #Péptidos Cíclicos #Conformación Proteica #Factor Reumatoide #Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies #Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Epitopes #Medical Subject Headings::Check Tags::Female #Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers #Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chains #Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans #Medical Subject Headings::Check Tags::Male #Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged #Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Protein Conformation #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Rheumatoid Factor #Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence::Amino Acid Motifs
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo