Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.

Autoria(s): Rodríguez-Martínez, JM; Velasco, C; García, I; Cano, ME; Martínez-Martínez, L; Pascual, A
Data(s)

26/07/2012

26/07/2012

01/06/2007
Resumo

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

This study was supported by the Dirección General de Investigación del Ministerio de Ciencia y Tecnología of Spain (project SAF2005-04704), the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (project PI060580), and the Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008) of Spain. This study was partially supported by a grant from Bayer.
Identificador

Rodríguez-Martínez JM, Velasco C, García I,Cano ME, Martínez-Martínez L, Pascual A.Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.Antimicrob Agents Chemother. 2007 Jun;51(6):2236-9.

0066-4804

http://hdl.handle.net/10668/425

10.1128/AAC.01444-06
Idioma(s)

en
Publicador

American Society for Microbiology
Relação

Antimicrobial Agents and Chemotherapy

http://aac.asm.org/content/51/6/2236.abstract
Direitos

Acceso restringido
Palavras-Chave #Mutant #prevention #fluoroquinolones #Enterobacteriaceae #quinolone resistance #Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Colony Count, Microbial #Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacterial #Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Escherichia coli Proteins #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones #Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests #Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids::Bacteriocin Plasmids #Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins #Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Escherichia coli Proteins #Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones #Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/published

Artículo
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