Preparation and antitubercular activity of lipophilic diamines and amino alcohols
| Data(s) |
01/08/2009
|
|---|---|
| Resumo |
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL. |
| Formato |
text/html |
| Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006 |
| Idioma(s) |
en |
| Publicador |
Instituto Oswaldo Cruz, Ministério da Saúde |
| Fonte |
Memórias do Instituto Oswaldo Cruz v.104 n.5 2009 |
| Palavras-Chave | #tuberculosis #amino alcohols #diamines #lipophilicity |
| Tipo |
journal article |
