Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.

This work was funded by research grants from the Spanish Ministry of Science and Innovation (BFU2007-28647-E, CSD2007-00015, PO7-CVI-02549 and ISCIII-RETIC-RD06/0020-FEDER) and the Junta de Andalucia (BIO-102). M.S. D-S was the recipient of a FPI predoctoral training grant from the Junta de Andalucía.