Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.


Autoria(s): Schmutz S.; Bosco N.; Chappaz S.; Boyman O.; Acha-Orbea H.; Ceredig R.; Rolink A.G.; Finke D.
Data(s)

2009

Resumo

During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+)CD3(-) cells are found in low numbers in lymphoid organs. Whether adult CD4(+)CD3(-) cells are LTi cells and are generated and maintained through cytokine signals has not been directly addressed. In this study we show that adult CD4(+)CD3(-) cells adoptively transferred into neonatal CXCR5(-/-) mice induced the formation of intestinal lymphoid tissues, demonstrating for the first time their bona fide LTi function. Increasing IL-7 availability in wild-type mice either by IL-7 transgene expression or treatment with IL-7/anti-IL-7 complexes increased adult LTi cell numbers through de novo generation from bone marrow cells and increased the survival and proliferation of LTi cells. Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool.

Identificador

http://serval.unil.ch/?id=serval:BIB_33F1CBA3DEF4

isbn:1550-6606[electronic]

pmid:19635901

doi:10.4049/jimmunol.0802911

isiid:000268906500005

Idioma(s)

en

Fonte

Journal of immunology, vol. 183, no. 4, pp. 2217-2221

Palavras-Chave #Animals; Antigens, CD3/metabolism; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; Cell Differentiation/genetics; Cell Differentiation/immunology; Cells, Cultured; Fetus/cytology; Fetus/immunology; Interleukin-7/biosynthesis; Interleukin-7/deficiency; Lymphangiogenesis/genetics; Lymphangiogenesis/immunology; Lymphoid Tissue/cytology; Lymphoid Tissue/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Receptors, Retinoic Acid/biosynthesis; Receptors, Retinoic Acid/deficiency; Receptors, Thyroid Hormone/biosynthesis; Receptors, Thyroid Hormone/deficiency; Spleen/cytology; Spleen/immunology; T-Lymphocyte Subsets/cytology; T-Lymphocyte Subsets/immunology
Tipo

info:eu-repo/semantics/article

article