Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil


Autoria(s): Medeiros,Luzidalva Barbosa de; Lacerda,Heloísa Ramos; Cavalcanti,Ana Maria Salustiano; Albuquerque,Maria de Fátima Pessoa Militão de
Data(s)

01/12/2006

Resumo

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800004

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.101 n.8 2006

Palavras-Chave #human imunodeficiency virus type 1 #primary resistance to drugs #genotyping #subtypes #Brazil
Tipo

journal article