Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-g and interleukin-4 mRNA expression


Autoria(s): Marques,Cláudia S; Rolão,Nuno; Centeno-Lima,Sónia; Lousada,Hélder; Maia,Carla; Campino,Lenea; Rosário,Virgílio E do; Silveira,Henrique
Data(s)

01/12/2005

Resumo

This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum. Expression of interferon-gamma (IFN<FONT FACE=Symbol>-g</FONT>) and interleukin-4 (IL-4) was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN<FONT FACE=Symbol>-g</FONT> expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000800011

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.100 n.8 2005

Palavras-Chave #co-infection #Plasmodium #Leishmania
Tipo

journal article