Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-g and interleukin-4 mRNA expression
Data(s) |
01/12/2005
|
---|---|
Resumo |
This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum. Expression of interferon-gamma (IFN<FONT FACE=Symbol>-g</FONT>) and interleukin-4 (IL-4) was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN<FONT FACE=Symbol>-g</FONT> expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection. |
Formato |
text/html |
Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000800011 |
Idioma(s) |
en |
Publicador |
Instituto Oswaldo Cruz, Ministério da Saúde |
Fonte |
Memórias do Instituto Oswaldo Cruz v.100 n.8 2005 |
Palavras-Chave | #co-infection #Plasmodium #Leishmania |
Tipo |
journal article |