Involvement of PPAR nuclear receptors in tissue injury and wound repair.


Autoria(s): Michalik L.; Wahli W.
Data(s)

2006

Resumo

Tissue damage resulting from chemical, mechanical, and biological injury, or from interrupted blood flow and reperfusion, is often life threatening. The subsequent tissue response involves an intricate series of events including inflammation, oxidative stress, immune cell recruitment, and cell survival, proliferation, migration, and differentiation. In addition, fibrotic repair characterized by myofibroblast transdifferentiation and the deposition of ECM proteins is activated. Failure to initiate, maintain, or stop this repair program has dramatic consequences, such as cell death and associated tissue necrosis or carcinogenesis. In this sense, inflammation and oxidative stress, which are beneficial defense processes, can become harmful if they do not resolve in time. This repair program is largely based on rapid and specific changes in gene expression controlled by transcription factors that sense injury. PPARs are such factors and are activated by lipid mediators produced after wounding. Here we highlight advances in our understanding of PPAR action during tissue repair and discuss the potential for these nuclear receptors as therapeutic targets for tissue injury.

Identificador

http://serval.unil.ch/?id=serval:BIB_2E99655B9A39

isbn:0021-9738

pmid:16511592

doi:10.1172/JCI27958

isiid:000235854300006

Idioma(s)

en

Fonte

Journal of Clinical Investigation, vol. 116, no. 3, pp. 598-606

Palavras-Chave #Animals; Humans; Ischemia; Peroxisome Proliferator-Activated Receptors; Wound Healing
Tipo

info:eu-repo/semantics/review

article