Intracellular pattern-recognition receptors


Autoria(s): Dostert C.; Meylan E.; Tschopp J.
Data(s)

2008

Resumo

The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail. More recently, cytoplasmic sensors were identified, which are capable of detecting not only microbial, but also self molecules. Importantly, while such receptors trigger crucial host responses to microbial insult, over-activity of some of them has been linked to autoinflammatory disorders, hence demonstrating the importance of tightly regulating their actions over time and space. Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm

Identificador

http://serval.unil.ch/?id=serval:BIB_2BE758463B35

isbn:0169-409X

pmid:18280002

doi:10.1016/j.addr.2007.12.003

isiid:000255693200008

Idioma(s)

en

Fonte

Advanced Drug Delivery Reviews, vol. 60, no. 7, pp. 830-840

Palavras-Chave #Animals ; Antiviral Agents ; Biochemistry ; biosynthesis ; Cytoplasm ; Dna ; Dna,Viral ; genetics ; Humans ; Immunity ; Interferon Type I ; Nod Signaling Adaptor Proteins ; pharmacology ; physiology ; Proteins ; Receptors,Pattern Recognition ; Rna ; Rna,Viral ; Switzerland ; therapeutic use
Tipo

info:eu-repo/semantics/review

article