Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing.
Data(s) |
2014
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Resumo |
AIM: Antidoping procedures are expected to greatly benefit from untargeted metabolomic approaches through the discovery of new biomarkers of prohibited substances abuse. RESULTS: Endogenous steroid metabolites were monitored in urine samples from a controlled elimination study of testosterone undecanoate after ingestion. A platform coupling ultra-high pressure LC with high-resolution quadrupole TOF MS was used and high between-subject metabolic variability was successfully handled using a multiblock data analysis strategy. Links between specific subsets of metabolites and influential genetic polymorphisms of the UGT2B17 enzyme were highlighted. CONCLUSION: This exploratory metabolomic strategy constitutes a first step toward a better understanding of the underlying patterns driving the high interindividual variability of steroid metabolism. Promising biomarkers were selected for further targeted study. |
Identificador |
http://serval.unil.ch/?id=serval:BIB_2B44DB382204 isbn:1757-6199 (Electronic) pmid:25411696 doi:10.4155/bio.14.200 isiid:000345341800003 |
Idioma(s) |
en |
Fonte |
Bioanalysis, vol. 6, no. 19, pp. 2523-2536 |
Tipo |
info:eu-repo/semantics/article article |