The role of APRIL and BAFF in lymphocyte activation.
| Data(s) |
2005
|
|---|---|
| Resumo |
The TNF family ligands BAFF (also called BLyS) and APRIL regulate lymphocyte survival and activation. BAFF binds to three receptors, BAFF-R, TACI and BCMA, whereas APRIL interacts with TACI, BCMA and proteoglycans. The contribution of BAFF and APRIL to B-cell and plasma-cell survival, CD154 (CD40L)-independent antibody isotype switching, germinal center maintenance, T-dependent and T-independent antibody responses, and T cell co-stimulation are relatively well understood. Constitutive BAFF produced by stromal cells determines the size of the peripheral B cell pool, whereas inducible BAFF produced by myeloid and other cells supports local survival of B lymphocytes and can be associated with development of autoimmunity when deregulated. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_2A4D71FFC1D3 isbn:0952-7915 (Print) pmid:15886118 doi:10.1016/j.coi.2005.04.005 isiid:000229555800010 http://my.unil.ch/serval/document/BIB_2A4D71FFC1D3.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_2A4D71FFC1D37 |
| Idioma(s) |
en |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Current Opinion in Immunology, vol. 17, no. 3, pp. 282-289 |
| Palavras-Chave | #Animals; B-Cell Activating Factor; B-Lymphocytes/immunology; Humans; Lymphocyte Activation/immunology; Membrane Proteins/metabolism; Mice; Receptors, Tumor Necrosis Factor; T-Lymphocytes/immunology; Tumor Necrosis Factor Ligand Superfamily Member 13; Tumor Necrosis Factor-alpha/metabolism |
| Tipo |
info:eu-repo/semantics/review article |
