Chronic bradykinin receptor blockade modulates neonatal renal function.


Autoria(s): Tóth-Heyn P.; Mosig D.; Guignard J.P.
Data(s)

2000

Resumo

Recent data indicate that bradykinin participates in the regulation of neonatal glomerular function and also acts as a growth regulator during renal development. The aim of the present study was to investigate the involvement of bradykinin in the maturation of renal function. Bradykinin beta2-receptors of newborn rabbits were inhibited for 4 days by Hoe 140. The animals were treated with 300 microg/kg s.c. Hoe 140 (group Hoe, n = 8) or 0.9% NaCl (group control, n = 8) twice daily. Clearance studies were performed in anesthetized rabbits at the age of 8-9 days. Bradykinin receptor blockade did not impair kidney growth, as demonstrated by similar kidney weights in the two groups, nor did it influence blood pressure. Renal blood flow was higher, while renal vascular resistance and filtration fraction were lower in Hoe 140-treated rabbits. No difference in glomerular filtration rate was observed. The unexpectedly higher renal perfusion observed in group Hoe cannot be explained by the blockade of the known vasodilator and trophic effect of bradykinin. Our results indicate that in intact kallikrein-kinin system is necessary for the normal functional development of the kidney.

Identificador

http://serval.unil.ch/?id=serval:BIB_28E1B090A6F9

isbn:0006-3126

pmid:10658830

doi:10.1159/000014194

isiid:000084369500007

Idioma(s)

en

Fonte

Biology of the Neonate, vol. 77, no. 1, pp. 45-49

Palavras-Chave #Adrenergic beta-Antagonists/pharmacology; Animals; Animals, Newborn; Blood Gas Analysis; Bradykinin/analogs & derivatives; Bradykinin/pharmacology; Cardiovascular Agents/pharmacology; Cardiovascular Agents/urine; Hematocrit; Indoles/pharmacology; Indoles/urine; Inulin/pharmacology; Inulin/urine; Kidney/growth & development; Kidney/physiology; Rabbits; Receptors, Bradykinin/antagonists & inhibitors; Receptors, Bradykinin/physiology; Urine/chemistry; p-Aminohippuric Acid/pharmacology; p-Aminohippuric Acid/urine
Tipo

info:eu-repo/semantics/article

article