Characterization of two receptors for TRAIL.
| Data(s) |
1997
|
|---|---|
| Resumo |
Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_25D695CC2FFE isbn:0014-5793 pmid:9373179 http://my.unil.ch/serval/document/BIB_25D695CC2FFE.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_25D695CC2FFE9 doi:10.1016/S0014-5793(97)01231-3 isiid:A1997YE70400023 |
| Idioma(s) |
en |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
FEBS letters, vol. 416, no. 3, pp. 329-34 |
| Palavras-Chave | #Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Chromosome Mapping; Cloning, Molecular; Humans; Kinetics; Lymphocytes; Membrane Glycoproteins; Molecular Sequence Data; Muscle, Skeletal; Polymerase Chain Reaction; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Tagged Sites; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha |
| Tipo |
info:eu-repo/semantics/article article |
