Plasmacytoid dendritic cells in melanoma: can we revert bad into good?


Autoria(s): Di Domizio J.; Demaria O.; Gilliet M.
Data(s)

2014

Resumo

Tumor-infiltrating plasmacytoid dendritic cells (pDCs) promote an immunosuppressive milieu that drives tumor growth in melanoma. This phenomenon typically results from the lack of appropriate pDC activation signals in the tumor microenvironment, but it is also actively controlled by tumor cells, which have evolved strategies to inhibit type I IFN production by pDCs. In this issue, Camisaschi et al. identify a new mechanism in which tumors avoid type I IFN production by triggering LAG-3-dependent activation of pDCs. Combination therapies that restore pDC functionality and trigger innate activation to produce type I IFN should be envisaged to induce effective antitumor immunity.

Identificador

http://serval.unil.ch/?id=serval:BIB_24B6406ACC3B

isbn:1523-1747 (Electronic)

pmid:24924760

doi:10.1038/jid.2014.155

isiid:000337333000005

Idioma(s)

en

Fonte

Journal of Investigative Dermatology, vol. 134, no. 7, pp. 1797-1800

Tipo

info:eu-repo/semantics/article

article