Target-guided synthesis of metal-based phosphatase inhibitors
| Contribuinte(s) |
Agència de Gestió d'Ajuts Universitaris i de Recerca Imperial College London |
|---|---|
| Data(s) |
10/02/2012
|
| Resumo |
Report for the scientific sojourn at the Imperial College of London, United Kingdom, from 2007 to 2009. PTEN is a tumour suppressor enzyme that plays important roles in the PI3K pathway which regulates growth, proliferation and survival and is thus related to many human disorders such as diabetes, neurodegenerative diseases, cardiovascular complications and cancer. It is hence of great interest to understand in detail its molecular behaviour and to find small molecules that can switch on/off its activity. For this purpose, metal complexes have been synthesized and preliminary studies in vivo show that all are capable of inhibiting PTEN. |
| Formato |
8 p. |
| Identificador | |
| Idioma(s) |
cat |
| Relação |
Els ajuts de l'AGAUR;2006 BP-A10030 |
| Direitos |
info:eu-repo/semantics/openAccess L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| Fonte |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
| Palavras-Chave | #Fosfatases #Antienzims #546 - Química inorgànica |
| Tipo |
info:eu-repo/semantics/other |
