The immunological synapse and actin assembly: a regulatory role for PKC theta.
| Data(s) |
2003
|
|---|---|
| Resumo |
Engagement of the T cell receptor leads to the accumulation of filamentous actin, which is necessary for the formation of the immunological synapse and subsequent T cell activation. In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and reveal a critical regulatory role for PKC theta in this process. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_22993368F1BB isbn:1534-5807[print], 1534-5807[linking] pmid:12530955 doi:10.1016/S1534-5807(02)00407-0 isiid:000180862000002 |
| Idioma(s) |
en |
| Fonte |
Developmental Cell, vol. 4, no. 1, pp. 3-5 |
| Palavras-Chave | #Actins/metabolism; Adaptor Proteins, Signal Transducing; Carrier Proteins/metabolism; Immunocompetence; Isoenzymes/metabolism; Lymphocyte Activation; Models, Immunological; Nuclear Proteins/metabolism; Protein Kinase C/metabolism; Proteins/metabolism; Receptors, Antigen, T-Cell/immunology; Signal Transduction; T-Lymphocytes/cytology; T-Lymphocytes/enzymology; Wiskott-Aldrich Syndrome Protein |
| Tipo |
info:eu-repo/semantics/article article |
