The type of K-ras mutation determines prognosis in colorectal cancer.


Autoria(s): Cerottini J.P.; Caplin S.; Saraga E.; Givel J.C.; Benhattar J.
Data(s)

1998

Resumo

BACKGROUND: Mutations involving the oncogene K-ras in colorectal cancer may be related to tumor aggressiveness. However, the value of K-ras gene determination as a prognostic marker has not been clearly established. PATIENTS AND METHODS: The results from 98 patients recruited in a prospective study analyzing the effect of a K-ras mutation as a prognostic factor in colorectal cancer are reported. RESULTS: Disease-free (P = 0.02) and overall survival (P = 0.03) were significantly reduced for patients harboring a K-ras mutation. Two specific mutations demonstrated a significantly increased risk of disease recurrence, namely, 12-TGT (P = 0.04) and 13-GAC substitutions (P = 0.002). Patients with either of these substitutions had a 2-year disease-free survival rate of 37% compared with that of 67% for the group of patients harboring any other mutation type or a wild-type status (P = 0.01). CONCLUSIONS: The results herein presented suggest that K-ras acts as a prognostic factor in colorectal cancer and that this effect is probably related to a limited number of defined mutations.

Identificador

http://serval.unil.ch/?id=serval:BIB_192E7021336A

isbn:0002-9610

pmid:9560119

doi:10.1016/S0002-9610(97)00283-3

isiid:000072714800008

Idioma(s)

en

Fonte

American journal of surgery, vol. 175, no. 3, pp. 198-202

Palavras-Chave #Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Disease-Free Survival; Female; Genes, ras; Humans; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Prognosis; Prospective Studies; Survival Analysis
Tipo

info:eu-repo/semantics/article

article