11
| Data(s) |
2014
|
|---|---|
| Resumo |
We describe here the potential of viral-mediated gene transfer for the modeling and treatment of Huntington's disease, focusing in particular on strategies for the tissue-specific targeting of various CNS cells. The protocols described here cover the design of lentiviral vectors, strategies for modifying their tropism, including the use of various envelopes and tissue-specific promoters, and the potential of miRNA to regulate transgene expression. |
| Identificador |
http://serval.unil.ch/?id=serval:BIB_156FC9B26D1E isbn:9781627036108 doi:10.1007/978-1-62703-610-8_11 |
| Idioma(s) |
en |
| Publicador |
New York: Humana Press |
| Fonte |
Viral Vectors in Neurobiology and Brain Diseases Lentiviral vectors in Huntington's disease research and therapy |
| Palavras-Chave | #Lentiviral vectors; tissue-specific promoters; pseudotyping; miRNA gene regulation; CNS; Huntington's disease |
| Tipo |
info:eu-repo/semantics/bookPart incollection |
