Study of humoral immune response in mammals immunized with Plasmodium falciparum antigenic preparations


Autoria(s): Cubas,Antonio B. Cruz; Cunha,Flavia; Nitcheu,Isére Kuiatse; Rolland,Laurence; Ciceron,Liliane; Carvalho,Alexandre B.; Furtado,André F.; Monjour,Loic
Data(s)

01/01/1992

Resumo

Six Plasmodium falciparum protein fractions, isolated under reducing conditions, were used to immunize mice, rabbits and the squirrel monkey Saimiri sciureus. Five or seven subcutaneous injections of each antigenic preparation, in conjunction with Freund's complete or incomplete adjuvants, were administered. This led to the development of specific antibodies detected by IFAT, ELISA or immunobloting which inhibited merozoite reinvasion in in vitro P. falciparum cultures. This activity seems to be associated with rhoptry proteins contained in fractions Pf F2 and Pf F4.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700072

Idioma(s)

en

Publicador

Instituto Oswaldo Cruz, Ministério da Saúde

Fonte

Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992

Palavras-Chave #Plasmodium falciparum #protein fractions #in vitro parasite inhibition #rhoptry proteins
Tipo

journal article