Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study).


Autoria(s): Marques-Vidal, P.; Bochud, M.; Bastardot, F.; von Känel, R.; Ferrero, F.; Gaspoz, J.M.; Paccaud, F.; Urwyler, A.; Lüscher, T.; Hock, C.; Waeber, G.; Preisig, M.; Vollenweider, P.
Data(s)

01/05/2012

Resumo

To assess the associations between alcohol consumption and cytokine levels (interleukin-1beta - IL-1β; interleukin-6 - IL-6 and tumor necrosis factor-α - TNF-α) in a Caucasian population. Population sample of 2884 men and 3201 women aged 35-75. Alcohol consumption was categorized as nondrinkers, low (1-6 drinks/week), moderate (7-13/week) and high (14+/week). No difference in IL-1β levels was found between alcohol consumption categories. Low and moderate alcohol consumption led to lower IL-6 levels: median (interquartile range) 1.47 (0.70-3.51), 1.41 (0.70-3.32), 1.42 (0.66-3.19) and 1.70 (0.83-4.39) pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p<0.01, but this association was no longer significant after multivariate adjustment. Compared to nondrinkers, moderate drinkers had the lowest odds (Odds ratio=0.86 (0.71-1.03)) of being in the highest quartile of IL-6, with a significant (p<0.05) quadratic trend. Low and moderate alcohol consumption led to lower TNF-α levels: 2.92 (1.79-4.63), 2.83 (1.84-4.48), 2.82 (1.76-4.34) and 3.15 (1.91-4.73) pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p<0.02, and this difference remained borderline significant (p=0.06) after multivariate adjustment. Moderate drinkers had a lower odds (0.81 [0.68-0.98]) of being in the highest quartile of TNF-α. No specific alcoholic beverage (wine, beer or spirits) effect was found. Moderate alcohol consumption is associated with lower levels of IL-6 and (to a lesser degree) of TNF-α, irrespective of the type of alcohol consumed. No association was found between IL-1β levels and alcohol consumption.

Identificador

https://serval.unil.ch/notice/serval:BIB_0817B7CF75BB

info:pmid:22420891

pmid:22420891

doi:10.1016/j.atherosclerosis.2012.02.011

isiid:000302960600039

Idioma(s)

eng

Fonte

Atherosclerosis2221245-250

Palavras-Chave #Adult; Aged; Alcohol Drinking; European Continental Ancestry Group; Female; Humans; Interleukin-1beta/blood; Interleukin-6/blood; Male; Middle Aged; Switzerland; Tumor Necrosis Factor-alpha/blood
Tipo

info:eu-repo/semantics/article

article