β-Arrestin2 influences the response to methadone in opioid-dependent patients.


Autoria(s): Oneda B.; Crettol S.; Bochud M.; Besson J.; Croquette-Krokar M.; Hämmig R.; Monnat M.; Preisig M.; Eap C.B.
Data(s)

2011

Resumo

β-Arrestin2 (ARRB2) is a component of the G-protein-coupled receptor complex and is involved in μ-opioid and dopamine D(2) receptor signaling, two central processes in methadone signal transduction. We analyzed 238 patients in methadone maintenance treatment (MMT) and identified a haplotype block (rs34230287, rs3786047, rs1045280 and rs2036657) spanning almost the entire ARRB2 locus. Although none of these single nucleotide polymorphisms (SNPs) leads to a change in amino-acid sequence, we found that for all the SNPs analyzed, with exception of rs34230287, homozygosity for the variant allele confers a nonresponding phenotype (n=73; rs1045280C and rs2036657G: OR=3.1, 95% CI=1.5-6.3, P=0.004; rs3786047A: OR=2.5, 95% CI=1.2-5.1, P=0.02) also illustrated by a 12-fold shorter period of negative urine screening (P=0.01). The ARRB2 genotype may thus contribute to the interindividual variability in the response to MMT and help to predict response to treatment.

Identificador

https://serval.unil.ch/?id=serval:BIB_02BE3E233F45

isbn:1473-1150 (Electronic)

doi:10.1038/tpj.2010.37

isiid:000293122100003

pmid:20514076

Idioma(s)

en

Direitos

info:eu-repo/semantics/openAccess

Fonte

Pharmacogenomics Journal, vol. 11, no. 4, pp. 258-266

Palavras-Chave #Adolescent; Adult; Aged; Analgesics, Opioid/therapeutic use; Arrestins/genetics; Chi-Square Distribution; Cross-Sectional Studies; Female; Gene Frequency; Genotype; Humans; Individualized Medicine; Logistic Models; Male; Methadone/therapeutic use; Middle Aged; Odds Ratio; Opiate Substitution Treatment; Opioid-Related Disorders/genetics; Opioid-Related Disorders/rehabilitation; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Retrospective Studies; Switzerland; Time Factors; Treatment Outcome; Young Adult
Tipo

info:eu-repo/semantics/article

article