Differential effects of two anti-apo-cytochrome c-specific monoclonal antibodies on the function of apo-cytochrome c-specific murine T cell clones.
Data(s) |
1984
|
---|---|
Resumo |
A murine monoclonal antibody (SJL 2-4) specific for the antigen apo-cytochrome c was shown to inhibit both antigen-induced proliferation and lymphokine secretion by an apo-cytochrome c-specific BALB/c helper T cell clone. The inhibition was specific because additional apo-cytochrome c-specific T cell clones were not inhibited by the same monoclonal antibody. Time course studies of the inhibition indicated that the initial 8 hr of contact between T cell clones and antigen-presenting cells were critical for activation of the T cell clones. Inhibition of T cell functions by antigen-specific antibodies appeared to correlate with the antibody-antigen binding constant because a second monoclonal antibody (Cyt-1-59), with identical specificity but with a lower affinity constant for apo-cytochrome c, had very little inhibitory effect on the proliferation or lymphokine secretion of apo-cytochrome c-specific T cell clones. |
Identificador |
https://serval.unil.ch/?id=serval:BIB_026E92235F36 isbn:0022-1767 (Print) pmid:6208267 isiid:A1984TT07900020 |
Idioma(s) |
en |
Fonte |
Journal of Immunology, vol. 133, no. 6, pp. 2915-2919 |
Palavras-Chave | #Animals; Antibodies, Monoclonal/physiology; Apoproteins/analysis; Apoproteins/immunology; Binding, Competitive; Cell Differentiation; Clone Cells/cytology; Clone Cells/immunology; Cytochrome c Group/analysis; Cytochrome c Group/immunology; Cytochromes c; Dose-Response Relationship, Immunologic; Epitopes/analysis; Kinetics; Lymphocyte Activation; Lymphokines/biosynthesis; Macrophage-Activating Factors; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes/cytology; T-Lymphocytes/immunology |
Tipo |
info:eu-repo/semantics/article article |