Side effects of genome structural changes.


Autoria(s): Reymond A.; Henrichsen C.N.; Harewood L.; Merla G.
Data(s)

2007

Resumo

The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.

Identificador

https://serval.unil.ch/?id=serval:BIB_014762682E1E

isbn:0959-437X[print], 0959-437X[linking]

pmid:17913489

doi:10.1016/j.gde.2007.08.009

isiid:000251349600003

Idioma(s)

en

Fonte

Current Opinion in Genetics and Development, vol. 17, no. 5, pp. 381-386

Palavras-Chave #Genetic Variation; Genome, Human; Humans; Polymorphism, Single Nucleotide/genetics; Sequence Analysis, DNA; Transcription, Genetic
Tipo

info:eu-repo/semantics/review

article