Synthesis and anticancer activity of N3-substituted-6,8-diaminopurines

[Excerpt] Cancer is the second most common cause of death in developed countries appearing just after cardiovascular diseases. The treatment of cancer remains a major medical challenge and the development of new anticancer drugs is an emerging topic for the scientific community. During the past three decades several chemical classes of anticancer drugs have been identified. In particular, 2,6-diamino purines proved to be important candidates as new anti-cancer agents.

FCT (NMR portuguese network; PhD Grant SFRH/BD/73721/2010); FCT and FEDER-COMPETE-QREN-EU [Pest-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)]