Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves


Autoria(s): Silva,Saulo Luis da; Figueiredo,Patrícia Maria; Yano,Tomomasa
Data(s)

01/06/2007

Resumo

Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (ß-caryophyllene, alpha-humulene, alpha -pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672007000200015

Idioma(s)

en

Publicador

Instituto Nacional de Pesquisas da Amazônia

Fonte

Acta Amazonica v.37 n.2 2007

Palavras-Chave #Zanthoxylum #Essential oil #cytotoxicity #ß-caryophyllene #alpha-humulene
Tipo

journal article