Serological survey for Chagas disease in the rural areas of Manaus, Coari, and Tefé in the Western Brazilian Amazon


Autoria(s): Magalhães,Belisa Maria Lopes; Coelho,Leíla Ines Aguiar Raposo Câmara; Maciel,Marcel Gonçalves; Ferreira,João Marcos Benfica Barbosa; Umezawa,Eufrozina Setsu; Coura,José Rodrigues; Guerra,Jorge Augusto de Oliveira; Barbosa,Maria das Graças Vale
Data(s)

01/12/2011

Resumo

INTRODUCTION: Deforestation, uncontrolled forest, human population migration from endemic areas, and the large number of reservoirs and wild vectors naturally infected by Trypanosoma cruzi promote the endemicity of Chagas disease in the Amazon region. METHODS: We conducted an initial serological survey (ELISA) in a sample of 1,263 persons; 1,095 (86.7%) were natives of the State of Amazonas, 666 (52.7%) were male, and 948 (75.1%) were over 20 years old. Serum samples that were found to be reactive, indeterminate, or inconclusive by indirect immunofluorescence (IFI) or positive with low titer by IFA were tested by Western blot (WB). Serologically confirmed patients (WB) were evaluated in terms of epidemiological, clinical, ECG, and echocardiography characteristics. RESULTS: Fifteen patients had serologically confirmed T. cruzi infection, and 12 of them were autochthonous to the state of Amazonas, for an overall seroprevalence of 1.2% and 0.9% for the state of Amazonas. Five of the 15 cases were males, and the average age was 47 years old; most were farmers with low education. One patient who was not autochthonous, having originated from Alagoas, showed right bundle branch block, bundle branch block, and anterosuperior left ventricular systolic dysfunction with an ejection fraction of 54%. CONCLUSIONS: The results of this study ratify the importance of monitoring CD cases in Amazonia, particularly in the state of Amazonas.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600009

Idioma(s)

en

Publicador

Sociedade Brasileira de Medicina Tropical - SBMT

Fonte

Revista da Sociedade Brasileira de Medicina Tropical v.44 n.6 2011

Palavras-Chave #Chagas Disease #Serological Survey #Brazilian Amazon
Tipo

journal article