Cytokine serum levels in patients infected by human immunodeficiency virus with and without Trypanosoma cruzi coinfection


Autoria(s): Rodrigues,Denise Bertulucci Rocha; Correia,Dalmo; Marra,Mônica Dias; Giraldo,Luis Eduardo Ramirez; Lages-Silva,Eliane; Silva-Vergara,Mario León; Barata,Cristina Hueb; Rodrigues Junior,Virmondes
Data(s)

01/12/2005

Resumo

This study assessed the number of CD4 T lymphocytes, the parasitemia and serum levels of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-4 and IL-10 of patients infected by human immunodeficiency virus (HIV) and human immunodeficiency virus/Chagas' disease coinfection. CD4 T lymphocytes were low in the two groups of patients, although significantly lower in patients without Chagas' disease. Serum levels of IFN-gamma, IL-4 and TNF-alpha were significantly higher in patients with HIV/Chagas' disease. IL-4/IFN-gamma ratios were higher in patients with HIV/Chagas' disease, which showed a clear balance in favor of Th2-like cytokines in this group of patients. This Th2 balance was higher in patients with detectable parasitemia. We conclude that, although immunosuppression was observed, with CD4 T lymphocytes bellow 200/µm³, these patients did not display reactivation of T. cruzi infection and that a balance favorable to Th2 was associated with the presence of parasitemia.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600007

Idioma(s)

en

Publicador

Sociedade Brasileira de Medicina Tropical - SBMT

Fonte

Revista da Sociedade Brasileira de Medicina Tropical v.38 n.6 2005

Palavras-Chave #Cytokine #Chagas' disease #Acquired immunodeficiency syndrome #Trypanosoma cruzi
Tipo

journal article