Cytokine serum levels in patients infected by human immunodeficiency virus with and without Trypanosoma cruzi coinfection
Data(s) |
01/12/2005
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Resumo |
This study assessed the number of CD4 T lymphocytes, the parasitemia and serum levels of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-4 and IL-10 of patients infected by human immunodeficiency virus (HIV) and human immunodeficiency virus/Chagas' disease coinfection. CD4 T lymphocytes were low in the two groups of patients, although significantly lower in patients without Chagas' disease. Serum levels of IFN-gamma, IL-4 and TNF-alpha were significantly higher in patients with HIV/Chagas' disease. IL-4/IFN-gamma ratios were higher in patients with HIV/Chagas' disease, which showed a clear balance in favor of Th2-like cytokines in this group of patients. This Th2 balance was higher in patients with detectable parasitemia. We conclude that, although immunosuppression was observed, with CD4 T lymphocytes bellow 200/µm³, these patients did not display reactivation of T. cruzi infection and that a balance favorable to Th2 was associated with the presence of parasitemia. |
Formato |
text/html |
Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600007 |
Idioma(s) |
en |
Publicador |
Sociedade Brasileira de Medicina Tropical - SBMT |
Fonte |
Revista da Sociedade Brasileira de Medicina Tropical v.38 n.6 2005 |
Palavras-Chave | #Cytokine #Chagas' disease #Acquired immunodeficiency syndrome #Trypanosoma cruzi |
Tipo |
journal article |