Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A)


Autoria(s): Fechio,Cristiane Jellmayer; Soares,Angela Maria Victoriano de Campos; Oliveira,Silvio Luís de; Sartori,Alexandrina
Data(s)

01/06/1999

Resumo

Leishmaniasis is a typical parasite infection whose protective immunity depends on macrophage activation. Susceptibility to Leishmania donovani infection was compared in H (high antibody responder) and L (low antibody responder) mice from selection IV-A. H mice infected intravenously with 10(7) amastigotes of L. donovani were more susceptible to infection than their L counterparts. This higher susceptibility was characterized by a higher splenic and hepatic parasite burden. An increased splenic index was observed in both lines after sixty days of infection. This splenomegaly was caused, at least partially, by an increase in the number of splenic cells as determined by direct counts of cells from spleen. The results show that selection IV-A is susceptible to visceral leishmaniasis, with the H line being more susceptible than the L line.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821999000300002

Idioma(s)

en

Publicador

Sociedade Brasileira de Medicina Tropical - SBMT

Fonte

Revista da Sociedade Brasileira de Medicina Tropical v.32 n.3 1999

Palavras-Chave #Leishmania donovani #Biozzi mice
Tipo

journal article