Mitchell-Riley Syndrome: A Novel Mutation in RFX6 Gene


Autoria(s): Amorim, M; Houghton, J; Carmo, S; Salva, I; Pita, A; Pereira-da-Silva, L
Data(s)

11/05/2016

11/05/2016

2015

Resumo

A novel RFX6 homozygous missense mutation was identified in an infant with Mitchell-Riley syndrome. The most common features of Mitchell-Riley syndrome were present, including severe neonatal diabetes associated with annular pancreas, intestinal malrotation, gallbladder agenesis, cholestatic disease, chronic diarrhea, and severe intrauterine growth restriction. Perijejunal tissue similar to pancreatic tissue was found in the submucosa, a finding that has not been previously reported in this syndrome. This case associating RFX6 mutation with structural and functional pancreatic abnormalities reinforces the RFX6 gene role in pancreas development and β-cell function, adding information to the existent mutation databases.

Identificador

Case Rep Genet. 2015 : 937201

http://hdl.handle.net/10400.17/2479

10.1155/2015/937201

Idioma(s)

eng

Publicador

Hindawi Publishing Corporation

Direitos

openAccess

Palavras-Chave #Mitchell-Riley Syndrome #RFX6 Gene #Case Report #HDE GEN #HDE CIR PED #HDE UCI NEO
Tipo

article