Hipotiroidismo Associado a Anticorpos Anti-Receptor da Hormona TSH com Ação Bloqueadora Determinada In Vitro


Autoria(s): Marques, P; Chikh, K; Charrié, A; Pina, R; Bugalho, MJ; Lopes, L
Data(s)

18/03/2016

18/03/2016

2015

Resumo

Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary cells were transfected with the recombinant human thyroid-stimulating hormone -receptor, and then exposed to the patient's serum; it was estimated a 'moderate' blocking activity of these thyroid-stimulating hormone-receptor autoantibodies, and concomitantly excluded stimulating action. In this case, the acknowledgment of the blocking activity of the serum thyroid-stimulating hormone-receptor autoantibodies, supported the hypothesis of a multifactorial aetiology of the hypothyroidism, which in the absence of the in vitro tests, we would consider only as a consequence of the destructive process associated to lymphocytic thyroiditis.

Identificador

Acta Med Port 2015 Sep-Oct;28(5):663-666

http://hdl.handle.net/10400.17/2428

Idioma(s)

por

Publicador

Centro Editor Livreiro da Ordem dos Médicos

Direitos

openAccess

Palavras-Chave #Hipotiroidismo #Doença de Graves #Receptores da Tireotropina #Tireoidite Autoimune #Criança #Caso Clínico #HDE END PED
Tipo

article