Warm Antibody Autoimmune Haemolytic Anaemia Associated with Ovarian Teratoma
Data(s) |
30/06/2015
30/06/2015
2010
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Resumo |
The ovarian cystic teratoma is a rare cause of autoimmune haemolytic anaemia by warm antibodies, resistant to corticotherapy, with few case reports published in the medical literature. We present a case of a 45-year-old woman admitted to hospital due to general weakness. Laboratory studies revealed macrocytic anaemia, biochemical parameters of haemolysis and peripheral spherocytosis. The direct Coombs test was positive. Viral serologies, anti-nuclear antibodies, anti-double-stranded DNA antibodies and β2-microglobulin were negative. CT scan of the thorax, abdomen and pelvis showed a heterogeneous right anexial lesion. The patient was treated with corticotherapy without improvement of anaemia. Regression of extra-vascular haemolysis and normalisation of haemoglobin was obtained only after laparoscopic splenectomy and right ooforectomy, and the histopathology of the right anexial mass revealed a cystic teratoma. Previously published cases controlled the haemolysis by surgically removing the lesion associated with splenectomy. |
Identificador |
BMJ Case Rep. 2010 May 19;2010. pii: bcr0620091971 |
Idioma(s) |
eng |
Publicador |
BMJ Publishing Group |
Direitos |
openAccess |
Palavras-Chave | #HSJ MED #HSJ ANPAT #HSJ CIR #Anemia, Hemolytic, Autoimmune/immunology #Coombs Test #Diagnosis, Differential #Laparoscopy #Ovarian Neoplasms/diagnosis #Ovarian Neoplasms/immunology #Ovarian Neoplasms/surgery #Ovariectomy #Splenectomy #Teratoma/diagnosis #Teratoma/immunology #Teratoma/surgery #Tomography, X-Ray Computed |
Tipo |
article |