Warm Antibody Autoimmune Haemolytic Anaemia Associated with Ovarian Teratoma


Autoria(s): Raimundo, P; Coelho, S; Cabeleira, A; Dias, L; Gonçalves, M
Data(s)

30/06/2015

30/06/2015

2010

Resumo

The ovarian cystic teratoma is a rare cause of autoimmune haemolytic anaemia by warm antibodies, resistant to corticotherapy, with few case reports published in the medical literature. We present a case of a 45-year-old woman admitted to hospital due to general weakness. Laboratory studies revealed macrocytic anaemia, biochemical parameters of haemolysis and peripheral spherocytosis. The direct Coombs test was positive. Viral serologies, anti-nuclear antibodies, anti-double-stranded DNA antibodies and β2-microglobulin were negative. CT scan of the thorax, abdomen and pelvis showed a heterogeneous right anexial lesion. The patient was treated with corticotherapy without improvement of anaemia. Regression of extra-vascular haemolysis and normalisation of haemoglobin was obtained only after laparoscopic splenectomy and right ooforectomy, and the histopathology of the right anexial mass revealed a cystic teratoma. Previously published cases controlled the haemolysis by surgically removing the lesion associated with splenectomy.

Identificador

BMJ Case Rep. 2010 May 19;2010. pii: bcr0620091971

http://hdl.handle.net/10400.17/2241

Idioma(s)

eng

Publicador

BMJ Publishing Group

Direitos

openAccess

Palavras-Chave #HSJ MED #HSJ ANPAT #HSJ CIR #Anemia, Hemolytic, Autoimmune/immunology #Coombs Test #Diagnosis, Differential #Laparoscopy #Ovarian Neoplasms/diagnosis #Ovarian Neoplasms/immunology #Ovarian Neoplasms/surgery #Ovariectomy #Splenectomy #Teratoma/diagnosis #Teratoma/immunology #Teratoma/surgery #Tomography, X-Ray Computed
Tipo

article