Biomimetic Sensor Potentiometric System for Doxycycline Antibiotic Using a Molecularly Imprinted Polymer as an Artificial Recognition Element


Autoria(s): Kamel, Ayman H.; Moreira, Felismina T. C.; Sales, M. Goreti F.
Data(s)

20/10/2015

20/10/2015

2011

Resumo

Molecular imprinting is a useful technique for the preparation of functional materials with molecular recognition properties. A Biomimetic Sensor Potentiometric System was developed for assessment of doxycycline (DOX) antibiotic. The molecularly imprinted polymer (MIP) was synthesized by using doxycycline as a template molecule, methacrylic acid (MAA) and/or acrylamide (AA) as a functional monomer and ethylene glycol dimethacrylat (EGDMA) as a cross-linking agent. The sensing elements were fabricated by the inclusion of DOX imprinted polymers in polyvinyl chloride (PVC) matrix. The sensors showed a high selectivity and a sensitive response to the template in aqueous system. Electrochemical evaluation of these sensors under static (batch) mode of operation reveals near-Nernstian response. MIP/MAA membrane sensor was incorporated in flow-through cells and used as detectors for flow injection analysis (FIA) of DOX. The method has the requisite accuracy, sensitivity and precision to assay DOX in tablets and biological fluids.

Identificador

http://hdl.handle.net/10400.22/6768

http://dx.doi.org/10.1166/sl.2011.1707

Idioma(s)

eng

Publicador

American Scientific Publishers

Relação

http://www.ingentaconnect.com/content/asp/senlet/2011/00000009/00000005/art00011?token=005a196ddea0693d07e442f2067217d766a445049796c2a406a687627504541676249266d656c8e26a1efe040d

Direitos

closedAccess

Tipo

article