Cardiac beta-receptors in experimental Chagas' disease
Data(s) |
01/02/1995
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Resumo |
Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. |
Formato |
text/html |
Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000100009 |
Idioma(s) |
en |
Publicador |
Instituto de Medicina Tropical |
Fonte |
Revista do Instituto de Medicina Tropical de São Paulo v.37 n.1 1995 |
Palavras-Chave | #Chagas' disease #beta receptors |
Tipo |
journal article |